Application of 14150-94-8 , The common heterocyclic compound, 14150-94-8, name is 1-Methyl-3,5-dinitro-1H-pyridin-2-one, molecular formula is C6H5N3O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a solution of dinitropyridone 1 (50.0 mg, 0.25 mmol) in ethanol (5 ml), were added enaminone 4a (38.8 mg, 0.25 mmol) and triethylamine (35mul, 0.25 mmol). The resultant mixture was heated at 100 C for 1 day. After evaporation, the residue was treated with column chromatography on alumina to afford 2-ethanoly-4-nitro-N-propylaniline (3a) (eluted with hexane/ethyl acetate = 8/2, 23.0 mg, 0.11 mmol, 43% (NMR Yield 63%)) as a yellow solid.
The synthetic route of 14150-94-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Naito, Saki; Yokoyama, Soichi; Asahara, Haruyasu; Nishiwaki, Nagatoshi; Tetrahedron Letters; vol. 58; 50; (2017); p. 4699 – 4702;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem