Synthetic Route of 10128-72-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10128-72-0, name is Methyl 3-hydroxyisonicotinate, molecular formula is C7H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of chloride (200mg, 1.0 mmol, 1.0 eq), and phenol (153 mg, 1.0 mmol, 1.0 eq) in DMF (15 mE) was added K2C03 (414 mg, 3.0 mmol, 3.0 eq) and the reaction mixture was heated at 80-90 C. for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/MeOR) to give the alkylation product. MS: exact mass calculated for C15R13N303, 283.10; mlz found, 284 [M+R].
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10128-72-0, Methyl 3-hydroxyisonicotinate.
Reference:
Patent; Global Blood Therapeutics, Inc.; The Regents of the University of Califorina; Cytokinetics, Inc.; Metcalf, Brian; Chuang, Chihyuan; Warrington, Jeffrey; Paulvannan, Kumar; Jacobson, Matthew P.; Hua, Lan; Morgan, Bradley; US2015/344483; (2015); A1;,
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