The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1020253-14-8, name is 6-Chloro-5-fluoronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H2ClFN2
Step 1: 6-(3-(4-((tert-butyldimethylsilyl)oxy)-2-chlorophenyl)-3-hydroxyazetidin-1-yl)-5-fluoronicotinonitrile (0270) A mixture of 26 3-(4-((tert-butyldimethylsilyl)oxy)-2-chlorophenyl)azetidin-3-ol hydrochloride (1c, 0.40 g, 1.1 mmol), 84 2-chloro-3-fluoropyridine-5-carbonitrile (0.18 g, 1.1 mmol), and 23 potassium carbonate (0.43 g, 3.1 mmol) in 8 DMF (2.5 mL) was heated at 65 C. for 30 minutes. The mixture was purified by flash chromatography (silica gel) to provide the desired 130 material. LCMS-ESI+(m/z): [M+H]+ calcd for C21H26ClFN3O2Si: 434.1; found: 434.0.
With the rapid development of chemical substances, we look forward to future research findings about 1020253-14-8.
Reference:
Patent; Gilead Sciences, Inc.; Blomgren, Peter A.; Currie, Kevin S.; Farand, Julie; Gege, Christian; Kropf, Jeffrey E.; Xu, Jianjun; (35 pag.)US2017/355693; (2017); A1;,
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