Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1033201-61-4, name is 6-Amino-3-bromopicolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Amino-3-bromopicolinic acid
A slurry of 6-amino-3-bromopicolinic acid (25 g) in 400 mL 1:1dichloromethane/chloroform was added to nitrosonium tetrafluoroborate (18.2 g) in dichloromethane(100 mL) at 5 oc over 1 hour. The resulting mixture was stirred for another 30 minutes, then warmed30 to 35 oc and stirred overnight. The reaction was cooled to room temperature, and then adjusted to pH4 with aqueous NaH2P04 solution. The resulting solution was extracted three times withdichloromethane, and the combined extracts were washed with brine, dried over sodium sulfate,filtered and concentrated to provide the title compound
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Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; SOUERS, Andrew, J.; PHILLIPS, Andrew, C.; JUDD, Andrew, S.; BRUNCKO, Milan; (717 pag.)WO2017/214282; (2017); A1;,
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