Adding a certain compound to certain chemical reactions, such as: 105596-63-2, 2-Methoxyisonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Methoxyisonicotinic acid, blongs to pyridine-derivatives compound. Quality Control of 2-Methoxyisonicotinic acid
General procedure: To a solution of acid (1 equiv.) inanhydrous DMF (0.18 M) was added EDCIHCl (1 equiv.), and HOBt (1 equiv.)successively in a sealed tube. The mixture was stirred at rt for 30 min.Carboximidamide (1 equiv.) was added in one portion and the reaction wasplaced in a pre-heated 130 C oil bath and continued to stir overnight. Waterwas added to quench the reaction and the mixture was extracted with EtOAc.The combined organic phase was washed with saturated aqueous sodiumbicarbonate solution, water, saturated aqueous sodium chloride, and dried overanhydrous Na2SO4. The organic phase was concentrated in vacuum and theresidue was subjected to silica gel chromatography to give the targetoxadiazole compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,105596-63-2, 2-Methoxyisonicotinic acid, and friends who are interested can also refer to it.
Reference:
Article; Yue, Xuyi; Dhavale, Dhruva D.; Li, Junfeng; Luo, Zonghua; Liu, Jialu; Yang, Hao; Mach, Robert H.; Kotzbauer, Paul T.; Tu, Zhude; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1011 – 1019;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem