Electric Literature of 117007-52-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 117007-52-0, name is 3-Iodo-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
Under an argon atmosphere, 10 g (40.81 mmol) of 3-iodo-1H-pyrazolo[3,4-b]pyridine (WO 2006/130673, Ex. 4b) and 14.63 g (44.89 mmol) of caesium carbonate were initially charged in 170 ml of N,N-dimethylformamide, and 12.3 g (44.89 mmol) of 1,1,1,2,2-pentafluoro-4-iodobutane, dissolved in 30 ml of N,N-dimethylformamide, were added. The mixture was stirred at room temperature for 2 days. Another 14.63 g (44.89 mmol) of caesium carbonate and 12.3 g (44.89 mmol) of 1,1,1,2,2-pentafluoro-4-iodobutane were then added. The mixture was stirred at room temperature over the weekend, and another 3.49 g (12.72 mmol) of 1,1,1,2,2-pentafluoro-4-iodobutane and 4.14 g (12.72 mmol) of caesium carbonate were added. After a further night at room temperature, 5 g (18.25 mmol) of 1,1,1,2,2-pentafluoro-4-iodobutane and 5.95 g (18.25 mmol) of caesium carbonate were added. After 6 days of stirring at room temperature, the mixture was heated at 70 C. for 2 days. The mixture was then cooled and filtered and the residue was washed with N,N-dimethylformamide. The filtrate was concentrated and purified by preparative HPLC (gradient 0.1% formic acid in water/60-90% methanol. This gave 5.48 g (34% of theory) of the title compound. LC-MS (Method 1): Rt=1.23 min; MS (ESIpos): m/z=392 (M+H)+ 1H NMR (400 MHz, DMSO-d6): delta [ppm]=2.85-3.02 (m, 2H), 4.81 (t, 2H), 7.33 (dd, 1H), 7.98 (dd, 1H), 8.65 (dd, 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 117007-52-0, 3-Iodo-1H-pyrazolo[3,4-b]pyridine.
Reference:
Patent; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Griebenow, Nils; Lang, Dieter; Wunder, Frank; Huebsch, Walter; Vakalopoulos, Alexandros; Tersteegen, Adrian; US2014/357637; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem