Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-71-1, name is 4,6-Dimethylpyridin-3-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 4,6-Dimethylpyridin-3-amine
[0096] A solution of methyl-4-bromobenzoate (1) (430 mg, 2mmol) and 4,6-dimethylpyridin-3-amine (2) (250 mg, 2.1 mmol) in toluene (8 mL) was prepared and the flask was closed. It was purged with nitrogen, then 2M solution of Al(CH3)3 in toluene (1.5 mL) was added drop-wise into the reaction mixture. After the addition was finished, the reaction was microwaved for 15 min at 110C. The reaction mixture was cooled down to room temperature, diluted with EtOAc (20mL), washed with 2N solution of NaOH (2 x lOmL) then brine (1×10 mL). Organic phase was collected and dried over a2S04. Column chromatography afforded 4-bromo-N-(4,6-dimethylpyridin-3-yl)benzamide (A) (yield over 80%).
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Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
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