Application of 1211517-76-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211517-76-8, name is 3-Bromo-5-fluoro-4-methylpyridine, molecular formula is C6H5BrFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2: A solution of the intermediate from step 1 (3.0 g, 15.8 mmol) and [1 ,1-Bis(diphenylphosphino)- ferrocene]dichloropalladium(ll) ( 0,7 g, 0.95 mmol) in ethylene glycol (70 mL) was purged with N2 before 1-(vinyloxy)butane (3.2 g, 31.6 mmol) and NEt3 (4.4 mL, 31.6 mmol) were added. The RM was stirred at 140C for 4 h. Water was added and the mixture extracted with CH2CI2. The combined organic layers were concentrated in vacuo, a solution of HCI (3 M, 30 mL) and THF (10 mL) added and the resulting solution stirred overnight. Water was added and the mixture extracted several times with EtOAc. The combined organic layers were dried, volatiles removed under reduced pressure and the residue purified by CC (Si02, Cy/EtAc) to yield the desired compound (0.77 g, 32%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211517-76-8, 3-Bromo-5-fluoro-4-methylpyridine.
Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem