Reference of 1228880-68-9, Adding some certain compound to certain chemical reactions, such as: 1228880-68-9, name is Methyl 3-bromo-5-methylpicolinate,molecular formula is C8H8BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1228880-68-9.
a) 3-(2-Methoxycarbonyl-vinyl)-5-methyl-pyridine-2-carboxylic acid methyl ester 3-Bromo-5-methyl-pyridine-2-carboxylic acid methyl ester (1.6 g, 6.945 mmol), methylacrylate (1.50 g, 17.39 mmol), allylpalladium(II) chloride dimer (0.127 g, 0.348 mmol), tri-o-tolylphosphine (0.212 g, 0.695 mmol), water free sodium carbonate (2.211 g, 20.9 mmol), and N,N.dimethylacetamide (4.56 ml) were added to toluene (15 ml) and the reaction mixture was stirred for 18 h at 115 C. in a microwave apparatus. The mixture was diluted with EtOAc, washed with brine, dried over sodium sulfate, and the solvents were evaporated under reduced pressure. The residue was purified by chromatography on silica (Flashmaster, hex to hex/EtOAc 2/3 over 40 min, 20 min hex/EtOAc 2/3) to give the product as off-white solid (1.31 g, 80%). [1H-NMR (DMSO-d6, 600 MHz) delta 8.51 (s, 1H), 8.20 (s, 1H), 8.10 (d, 1H), 6.69 (d, 1H), 3.88 (s, 3H), 3.74 (s, 3H), 2.39 (s, 3H); LCMS RtL=2.753 min; [M+H]+=236.0]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1228880-68-9, Methyl 3-bromo-5-methylpicolinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; US2012/258973; (2012); A1;,
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