Adding a certain compound to certain chemical reactions, such as: 127356-26-7, 6-Methoxypyridine-3,4-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 6-Methoxypyridine-3,4-diamine, blongs to pyridine-derivatives compound. Application In Synthesis of 6-Methoxypyridine-3,4-diamine
To a solution of 6-methoxypyridine-3,4-diamine (0.45 g, 3.23 mmol) in ethanol was added ethyl trifluoropyruvate (0.393 mL, 3.23 mmol). The reaction mixture was heated to reflux at 90 C. for 16 h. The volatiles were removed under reduced pressure. To the residue was added Pet-ether. The resultant solid was isolated via filtration and dried to afford 7-methoxy-3-(trifluoromethyl)pyrido[3,4-b]pyrazin-2-ol and 7-methoxy-2-(trifluoromethyl)pyrido[3,4-b]pyrazin-3-ol as mixture of regioisomer (0.37 g 46% yield). MS: MS m/z 246.2 (M++1).; A solution of 7-methoxy-3-(trifluoromethyl)pyrido[3,4-b]pyrazin-2-ol and 7-methoxy-2-(trifluoromethyl)pyrido[3,4-b]pyrazin-3-ol (0.37 g, 1.509 mmol) in POCl3 (5 mL) was heated to 100 C. for 2 h. The solvent was removed under reduced pressure and the residue was diluted with ice cold water. The aqueous solution was basified to pH ?9.0 by using sodium bicarbonate, then was extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography using 10% ethyl acetate in Pet-ether to get 2-chloro-7-methoxy-3-(trifluoromethyl)pyrido[3,4-b]pyrazine (0.135 g, 0.435 mmol, 28.8% yield) and 3-chloro-7-methoxy-2-(trifluoromethyl)pyrido[3,4-b]pyrazine (0.035 g, 0.435 mmol, 4.8% yield) as yellow solids.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,127356-26-7, 6-Methoxypyridine-3,4-diamine, and friends who are interested can also refer to it.
Reference:
Patent; Bristol-Myers Squibb Company; Sun, Li-Qiang; Zhao, Qian; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Gillis, Eric P.; Scola, Paul Michael; (81 pag.)US9643999; (2017); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem