In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1289093-31-7, name is 5-Bromo-3-chloro-2-isobutoxypyridine, the common compound, a new synthetic route is introduced below. name: 5-Bromo-3-chloro-2-isobutoxypyridine
To a mixture of 6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbonitrile (step 5) (220 mg, 1.2 mmol) in dioxane (20 ml) was added 5-bromo-3-chloro-2-isobutoxypyridine (intermediate A) (980 mg, 3.7 mmol), CuI (470 mg, 2.5 mmol), K2CO3 (341 mg, 2.5 mmol), and DMEDA (260 mg, 2.5 mmol). After addition, the mixture was degassed and charged with N2 three times. Then the mixture was heated to 110 C. and stirred at that temperature under N2 atmosphere for 16 hrs. When LC/MS indicated the starting material was consumed, the reaction mixture was diluted with DCM (200 ml). The mixture was filtered over celite. The filtration was washed with brine (*3), dried over anhydrous Na2SO4 and filtered. The filtration was evaporated to afford a residue, which was purified by flash column chromatography on silica gel using a gradient 0-20% ethyl acetate in hexanes to afford the title compound as white solid. LC-MS: Rt=1.27 mins; MS m/z [M+H]+ 362.0; Method 5-95AB 1.5minLC_v003 1H NMR (400 MHz, CDCl3) delta 7.96 (1H, d), 7.56 (1H, d), 6.98 (1H, d), 6.22 (1H, d), 4.31 (2H, m), 4.11 (2H, d), 3.68 (2H, m), 2.16 (1H, m), 1.05 (6H, d).
The synthetic route of 1289093-31-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; CHEN, Shuhui; HE, Haiyang; LAGU, Bharat; QIN, Hua; WU, Chengde; XIAO, Yisong; US2015/183802; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem