Adding a certain compound to certain chemical reactions, such as: 13466-43-8, 3-Bromopyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 3-Bromopyridin-2(1H)-one, blongs to pyridine-derivatives compound. Quality Control of 3-Bromopyridin-2(1H)-one
(c) 3-Bromo-2-methoxypyridine Under an argon atmosphere, a mixture of 3-bromo-2-hydroxypyridine (3.49 g, 20 mmol), silver carbonate (3.67 g, 13.31 mmol), and iodomethane (1.5 mL, 24.1 mmol) in benzene (30 mL) was stirred in the dark at 40 C. to 50 C. for 24 hours, cooled in an ice bath, and filtered. The filtrate was washed once with 2% aqueous sodium bicarbonate and twice with water, dried (MgSO4), the benzene was evaporated at atmospheric pressure, and the residue was purified by flash chromatography (eluding with hexane/ethyl acetate, 2:1) to obtain the title compound (2.35 g, 12.5 mmol, 62%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13466-43-8, 3-Bromopyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Astra Aktiebolag; US6110914; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem