Electric Literature of 14916-65-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14916-65-5, name is 6-Nitropyridin-3-amine, molecular formula is C5H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-chlorobenzaldehyde (84.3 g, 0.6 mol) 5-amino-2-nitropyridine (70.0 g, 0.5 mol) and acetic acid (7.2 g, 0.12 mol) were dissolved in ethanol (350 ml) and stirred at room temperature for 1 hour. The reaction system was heated to reflux and TLC was detected.After completion of the reaction, the reaction solution was cooled to room temperature and then filtered, and the filter cake was washed with ethanol (100 mL x 3)The crude oil was recrystallized to give yellow solid compound 28 (104.6 g, yield 80%).
According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Haoyuan Bio-pharmaceutical Technology Co., Ltd.; Shanghai Haoyuan Pharmaceutical Co., Ltd.; Xia Junwei; Xun Hengqiao; Wang Yefa; Zhou Zhiguo; Gao Qiang; Zheng Baofu; (20 pag.)CN105017219; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem