Sources of common compounds: 16063-70-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-70-0, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 16063-70-0, 2,3,5-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16063-70-0, blongs to pyridine-derivatives compound. 16063-70-0

To a solution of ethyl (2E) -3- [2-hydroxy-4- (2- methoxyethoxy) phenyl] acrylate (900 mg) in N,N- dimethylformamide .(15 ml) was added sodium hydride (60% in oil, 188 mg) , and the mixture was stirred at room temperature for 1 hr. 2, 3, 5-Trichloropyridine (925 mg) was added to the reaction mixture, and the. mixture was stirred at 800C for 36 hr. After cooling, water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) , and concentrated. The obtained residue was subjected to silica EPO gel column chromatography, and eluted with ethyl acetate- hexane (1:4, v/v) . The obtained crude crystals were recrystallized from ethyl acetate-hexane to give ethyl (2E) -3- [2- [ (3, 5-dichloropyridin-2-yl) oxy] -4- (2- methoxyethoxy) phenyl] acrylate (1.01 g, yield: 72%) as colorless crystals, melting point 70.7-71.30C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-70-0, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem