Sources of common compounds: 16744-81-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16744-81-3, 4-Methoxypicolinaldehyde, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 16744-81-3, Adding some certain compound to certain chemical reactions, such as: 16744-81-3, name is 4-Methoxypicolinaldehyde,molecular formula is C7H7NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16744-81-3.

Examples; Final products; 1. (R. S)-2- [3-F4-METHOXYPYRIDIN-2-Y)) PROP-2-Y .]-3H-IMIDAZO [4. 5-B] PYRIDINE HYDROCHTORIDE; A solution of 0.59 g of 4METHOXYPYRIDINE-2-CARBALDEHYDE (Ashimori et al., Chem. Pharm. Bull. 38,2446- 2458 (1990) ) in 19 ml of methanol is treated with 1.9 g of {1- (3H-imidazo [4,5-b] pyridin-2-yl)-ethyl}- triphenyl-phosphonium chloride (compound A1). 3.3 ml of a solution of sodium methanolate in methanol (1.3 M) are added dropwise at 50° C. The reaction mixture is stirred at 50°C for 4 h and evaporated to dryness. The resulting residue is chomatographed on silica gel using DICHLOROMETHANE/METHANOL 20: 1 to give 1.75 g of a colorless, amorpheous solid, which is dissolved in 190 ml of methanol. 1.5 ml of glacial acetic acid and 388 mg of palladium on active carbon (10percent Pd) are added and the suspension is stirred at room temperature for 2.5 d under hydrogen atmosphere. Then the catalyst is filtered off and the reaction mixture is concentrated to dryness. After CHROMATOGRAPHICAL purification of the residue on silica gel (DICHOROMETHANE/METHANOL 25: 1) and evaporation of the eluents, 837 mg of an oil are obtained, which is dissolved in 160 ml of DICHLOROMETHANE. 2 ml of an ethereal hydrochloric acid solution (2.0 M) are added to the solution under ice-cooling. After LYOPHILLIZATION from dioxane, 0.951 g of the title compound are obtained as a colorless LYOPHILISATE. M. p. 61 °-64°C. MS: 269.1 (MH+). TLC: Rf = 0.44 (dichloromethane/methanol 10: 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16744-81-3, 4-Methoxypicolinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALTANA PHARMA AG; WO2005/30768; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem