Adding a certain compound to certain chemical reactions, such as: 175204-80-5, 3-Amino-4-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 175204-80-5, blongs to pyridine-derivatives compound. Computed Properties of C6H5F3N2
The 3-amino-4-trifluoromethylbenzoate methylpyridinio (5g, 30.8mmol) was added to the 50% sulfuric acid (50 ml) at -5 C dropped in NaNO 2 (2.55g, 37 . 0mmol) aqueous solution (10 ml). Transfer to is omitted the reaction at room temperature 30 minutes, then to the reaction system by adding concentrated sulfuric acid (25 ml), heating to 110 C to continue reaction 2 hours. After the reaction, using NaHCO 3 adjusting pH to 6-7, then extracted with ethyl acetate (3×100 ml), the organic phase is dried with anhydrous sodium sulfate, filtered, concentrated, to obtain the title compound (4.8g, yield 95.4%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175204-80-5, its application will become more common.
Reference:
Patent; Shandong Xuan Bamboo Pharmaceutical Technology Co., Ltd.; Wu, Yong qian; (49 pag.)CN105461714; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem