With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.175965-83-0, name is 2-Fluoro-4-methoxypyridine, molecular formula is C6H6FNO, molecular weight is 127.12, as common compound, the synthetic route is as follows.name: 2-Fluoro-4-methoxypyridine
Method Z Step l To a solution of F6 (40.0 mg, 0.098 mmol) and 2-fiuoro-4-methoxypyridine (25.0 mg, 0.197 mmol) in DMSO (2 mL) was added Cs2C03 (96.0 mg, 0.295 mmol). The mixture was stirred at 1 10 C for 1 h under microwave condition, and then quenched with water, extracted with EtOAc (25 mL x 4). The combined extracts were washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was further purified by p-HPLC (TFA) to give Example 71.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,175965-83-0, 2-Fluoro-4-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; CUMMING, Jared, N.; LIU, Hong; SCOTT, Jack, D.; (0 pag.)WO2016/85780; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem