Adding a certain compound to certain chemical reactions, such as: 1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H7Cl2N, blongs to pyridine-derivatives compound. Computed Properties of C6H7Cl2N
General procedure: Intermediate 9a (or 9b, 0.5 mmol) was dissolved in anhydrous DMF (10 mL) in the presenceof anhydrous K2CO3 (0.14 g, 1 mmol), followed by addition of appropriate substituted benzyl chloride (or 4-picolyl chloride hydrochloride) (0.5 mmol). The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, and water (20 mL) was added. Extracted with ethyl acetate (2 × 10 mL), and the organic phase was washed with saturated sodium chloride solution (10 mL), and dried over anhydrous Na2SO4, which was purified by flash column chromatography to afford title compounds 10a1~a3 and 10b1~b3.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Article; Chen, Xuwang; Liu, Xin; Meng, Qing; Wang, Ding; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Balzarini, Jan; Liu, Xinyong; Bioorganic and Medicinal Chemistry Letters; vol. 23; 24; (2013); p. 6593 – 6597;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem