Application of 18368-63-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18368-63-3, name is 2-Chloro-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
2-Chloro-6-methylpyridine 4a (5 g, 39.19 mmol, prepared by a known method “Journal of Chemical Research-Part S, 1996, 4, 194-195”),4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bis(1,3,2-dioxaborolane)(10.95g, 43.11mmol), (1,5-cyclooctadiene)methoxy ruthenium(I) dimer (779 mg, 1.18 mmol) and 4,4′-di-tert-butyl-2,2′-dipyridine (631 mg, 2.35 mmol) were dissolved in 125 mL of n-hexane, heated to 80 C and stirred for 17 hours. The reaction was stopped, cooled to room temperature and concentrated under reduced pressure.The residue was purified by thin layer chromatography using a developing solvent system B.The title compound 4b (4.9 g, yield: 49.31%) was obtained.
According to the analysis of related databases, 18368-63-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Lu Biao; Wang Shenglan; Shen Xiaodong; He Feng; Tao Weikang; (56 pag.)CN109535161; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem