Electric Literature of 98549-88-3 ,Some common heterocyclic compound, 98549-88-3, molecular formula is C7H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of formula 8 (R=methyl and X=F, 100 g), formula 7 (152 g), potassium phosphate (190 g),and diglyme were stirred at 1 1 OmicronC for 20-22 hours. Afte r cooling, the reaction mixture was filtered through a Celite bed and the filtrate was washed with diglyme (150 mL). Activated carbon (10 g) was charged and the mixture was stirred for 1 hour. The reaction mass was filtered through a Celite bed and the filtrate was washed with diglyme. Water (3000 mL)was added to the mother liquor and the mixture was stirred at 0- 5C for 2 hours. The mixture was then filtered and the obtained solid was washed with water (450 mL) then dried at 60C under vacuum. Toluene was added and the mixture was stirred at 80C. After cooling to 0-5C, the reaction mixture stirred for 2 hours, filtered, and the obtained solid was washed with chilled toluene. The solid was suck dried then dried under vacuum (50mm Hg) at 50 (80g, Yield: 0.8 w/w).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98549-88-3, its application will become more common.
Reference:
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
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