Adding a certain compound to certain chemical reactions, such as: 1137-68-4, 2-(2-Pyridyl)benzimidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1137-68-4, blongs to pyridine-derivatives compound. Computed Properties of C12H9N3
The 2-(pyridin-2-yl)-1H-benzo[d]imidazole (2.0g, 0.0102 mol)was dissolved in 30 ml of dry DMF and stirred with potassiumcarbonate (1.4g, 0.0102 mol) at room temperature for 1 h and 2-(Bromomethyl naphthalene) (2.2. g, 0.0102 mol) was dissolved in20 ml of THF then added dropwise using dropping funnel proceedthe reaction for further 12 h. The proceeding of product waschecked by thin layer chromatography. After the completion ofreaction solvent was rescued under vacuum, the resulting solidswere treated with 30 ml of HCl washed using ethyl acetate anddistilled water. The separated organic layer is filtered over sodiumsulphate then the compound was purified under column chromatographytechnique (Hexane: ethyl acetate-10:90) to obtain whitesolid as the product. Yield 78%, 1H NMR (500 MHz, CDCl3) d 8.51 (d,J 4.3 Hz, 1H), 8.37 (d, J 8.0 Hz, 1H), 7.85e7.52 (m, 5H), 7.45 (s,1H), 7.33e7.05 (m, 7H), 6.25 (s, 2H). 13C NMR (126 MHz, CDCl3)d 150.52, 150.01, 148.68, 142.72, 136.92, 134.97, 133.29, 132.71,128.45, 127.81, 127.61, 126.22, 125.88, 125.40, 124.89, 124.75, 123.92,123.69, 122.93, 120.16, 49.20. HRMS (ESI): calcd. For [MH]C23H17N3 336.1495 found 336.1497. The data is given in supp. data eFig. S4aec.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1137-68-4, its application will become more common.
Reference:
Article; Balamurugan, Selvaraj; Ganesan, Shanmugam; Electrochimica Acta; vol. 329; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem