Application of 13362-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13362-28-2, name is 2-Amino-4-pyridinecarboxylic acid. A new synthetic method of this compound is introduced below.
[0258] To a solution of [4-(5-methyl-l,2,4-oxadiazol-3-yl)phenyl]methanamine (95 mg, 0.50 mmol, 1.00 equiv) in DMF (4 mL) were added 2-aminopyridine-4-carboxylic acid (69.5 mg, 0.50 mmol, 1.00 equiv) and DIPEA (100 mg, 0.77 mmol, 1.50 equiv) at r.t. The mixture was stirred at r.t. for 10 min, added HATU (230 mg, 0.60 mmol, 1.20 equiv), stirred for 15 ht., filtered, concentrated, and purified by Prep-HPLC with the following conditions: (2- AnalyseHPLC-SHIMADZU(HPLC-lO)): Column, Gemini-NX C18 AXAI Packed, (0797) 2l.2*l50mm 5um; mobile phase, water (0.05% NH3H2O) and ACN (33.0% ACN up to 41.0% in 5 min); Detector, uv 254nm. to afford 6.9 mg (4%) of 2-amino-/V-[[4-(5-methyl-l,2,4- oxadiazol-3-yl)phenyl]methyl]pyridine-4-carboxamide as a white solid. LRMS (ES) m/z 310 (M+H). 1H-NMR: (DMSO, 400 MHz , rrhi): d 9.14-9.11 (1H, t, / = 6.0), 7.99-7.93 (3H, m), 7.46-7.44 (2H, d, / = 8.0), 6.86-6.83 (2H, m), 7.54-7.47 (3H, m), 6.14 (2H, s), 4.50-4.48 (2H, d, / = 6.0), 2.80 (1H, s), 2.63 (3H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13362-28-2, its application will become more common.
Reference:
Patent; CYTOKINETICS, INC.; MORGAN, Bradley P.; VANDERWAL, Mark; CHUANG, Chihyuan; (0 pag.)WO2020/5888; (2020); A1;,
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