With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6602-32-0, name is 2-Bromo-3-hydroxypyridine, molecular formula is C5H4BrNO, molecular weight is 174, as common compound, the synthetic route is as follows.HPLC of Formula: C5H4BrNO
Preparation 1022-Bromo- -difluoromethoxypyridineTo a solution of 2-bromo-3-pyridinol (1 .26 g, 7.23 mmol) in DMF (35 mL) and water (5 mL) was added sodium chlorodifluoroacetate (2.93 g, 18.1 mmol) followed by cesium carbonate (4.71 g, 14.5 mmol). The reaction was heated to 100 C for 36 hours before partitioning between EtOAc and water. The organic layer was collected, dried over magnesium sulfate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with EtOAc:heptane 1 :3 to afford the title compound as a colourless oil (570 mg, 35%).1H NMR (400 MHz; DMSO-d6): delta 7.15-7.55 (t, 1 H), 7.55 (m, 1 H), 7.80 (m, 1 H), 8.25 (m, 1 H).LCMS Rt = 1 .91 minutes MS m/z 226 [M79BrH]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6602-32-0, 2-Bromo-3-hydroxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER LIMITED; BROWN, Alan Daniel; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan; WO2012/7869; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem