Synthetic Route of 6602-32-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6602-32-0, name is 2-Bromo-3-hydroxypyridine, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of triphenylphosphine (6.31 g, 24.1 mmol) and DEAD (4.49, 25.8 mmol) in THF (30 mL) at 0 Cwas added a solution of 3 (3.10 g, 17.2 mmol) and 2-bromopyridin-3-ol 4 (3.44 g, 19.8 mmol) in THF (20 mL). The resulting luminous yellow solution was stirred under a nitrogen atmosphere at ambient temperature for 24 h at which all starting materials had been consumed. The solvent was removed, the residue was purified by flash chromatography on silica gel eluting with EtOAc/petroleum ether (1%-20%) to give 5 as light yellow liquid (4.97 g, 86%). 1H NMR (400 MHz, DMSO-d6) delta 8.06 (s, ArH, 1H), 7.92 (dd, J = 1.2, ArH, 4.4 Hz, 1H), 7.88 (d, J = 7.6 Hz, ArH, 1H), 7.72 (d, J = 7.6 Hz, ArH, 1H), 7.54 (t, J = 7.8 Hz, ArH, 1H), 7.45 (dd, J = 1.2, 8.0 Hz, ArH, 1H), 7.29 (dd, J = 4.8, 8.0 Hz, ArH, 1H), 5.84 (q, J = 6.4 Hz, CH, 1H), 3.86 (s, OCH3, 3H), 1.62 (d, J = 6.4 Hz, CH3, 3H). ESI-MS m/z: 336.6 and 338.5 [M+H]+.
According to the analysis of related databases, 6602-32-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tian, Yuanxin; Zhang, Tingting; Long, Lifan; Li, Zhonghuang; Wan, Shanhe; Wang, Guangfa; Yu, Yonghuan; Hou, Ju; Wu, Xiaoyun; Zhang, Jiajie; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 182 – 199;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem