Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1086381-43-2, name is 2-Bromo-4-isopropylpyridine. A new synthetic method of this compound is introduced below., SDS of cas: 1086381-43-2
To a heat dried flask, phenylboronic acid (319.9 mg, 1.05 equiv., 2.624 mmol), potassium carbonate (1.036 g, 3 equiv., 7.5 mmol) and palladium(ii) acetate (56 mg, 0.1 equiv., 0.24990mmol%) were added. The flask was sealed and vacuumed and backfilled with nitrogen 3 times. Degassed ethanol (11.3 mL, 0.22 1 M) and water (2.8 mL, 0.885 M) were added, followed by 2-bromo-4-isopropyl-pyridine (500 mg, 2.4990 mmol), and the reaction was heated to 80C. The reaction was ran overnight, then was cooled to room temperature, was filtered through silica gel(isopropyl acetate eluting). The crude reaction was concentrated and purified by column chromatography to give a pale yellow oil (118.4 mg, 24% yield). 1H NMR (400 MHz, Chloroform-d) delta 8.58 (d, J = 5.2 Hz, 1H), 8.02 – 7.90 (m, 2H), 7.59- 7.54 (m, 1H), 7.50-7.34 (m, 4H), 7.08 (dd, J = 5.2, 1.6 Hz, 1H), 2.94 (hept, J = 6.9 Hz, 1H), 1.29 (d, J = 7.0 Hz, 6H).
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Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; BERGERON, Phillipe; BURFORD, Kristen; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HASAN, Abid; LAI, Kwong Wah; LIU, Zhiguo; MCKERRALL, Steven; NGUYEN, Teresa Phuongtram; SAFINA, Brian; SUTHERLIN, Daniel; TAN, Wang Tao; (470 pag.)WO2017/58821; (2017); A1;,
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