In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 175205-81-9
Step B: 2-[3-ethylsulfonyl-5-[4-(trifluoromethyl)-2-pyridyll-2-pyridyll-3,5-dimethyl-6- (trifluoromethyl)imidazo[4,5-clpyridin-4-one (compound A42): A 5mL microwave vial flushed with Argon was charged with 2-bromo-4-(trifluoromethyl)pyridine (0.2656 g, 1.140 mmol), 2-[3-ethylsulfonyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-2-pyridyl]- 3,5-dimethyl-6-(trifluoromethyl)imidazo[4,5-c]pyridin-4-one (Step A, 0.3 g, 0.57 mmol), tetrakis (triphenylphosphine) palladium(O) (0.066 g, 0.057 mmol), potassium phosphate tribasic (0.7484 g, 3.420 mmol), toluene (2 mL) and water (2 mL). The mixture was then heated 15′ at 1 10¡ãC under microwave. The reaction mixture was diluted with water and ethyl acetate then, after separation of the phases, the aqueous phase was extracted two time with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated under vacuum. The residue was subjected to column chromatography over silica gel, eluting with ethyl acetate / cyclohexane. The selected fractions were evaporated to yield the title compound as a white solid (90 mg). H NMR (400 MHz, CDCI3) delta ppm 1.41 (t, 3 H), 3.75 (s, 3 H), 3.85 (q, 2 H), 4.13 (s, 3 H), 7.25 (s, 1 H), 7.67 (d, 1 H), 8.12 (s, 1 H), 9.02 (d, 1 H), 9.12 (s, 1 H), 9.65 (s, 1 H).
The synthetic route of 175205-81-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JUNG, Pierre Joseph Marcel; EDMUNDS, Andrew; JEANGUENAT, Andre; MUEHLEBACH, Michel; STOLLER, Andre; EMERY, Daniel; HALL, Roger Graham; (126 pag.)WO2016/23954; (2016); A2;,
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