Reference of 727356-19-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.727356-19-6, name is 2-Bromo-6-(chloromethyl)pyridine, molecular formula is C6H5BrClN, molecular weight is 206.47, as common compound, the synthetic route is as follows.
Step 3; Preparation of trans-4-{[5-(6-bromopyridin-2-yl)thiazol-2-ylamino]methyl}cyclohexanecarboxylic acid methyl ester A solution of trans-4-thiouredide methylcyclohexane carboxylic acid methyl ester (1.55 g, 6.73 mmol) obtained in Step 2,2-bromo-6-chloromethylpyridine (1.38 g, 6.73 mmol) obtained in Step 1 of Example 1 in ethanol (15 ml) was stirred under refluxing for 4 hours. After the reaction solution was cooled to room temperature, N,N-dimethylformamide dimethylacetal (0.9 ml, 10 mmol), triethylamine (1.8 ml, 20 mmol) were added and the mixture was stirred under refluxing for 1 hour. The reaction solution was cooled to room temperature and the solid obtained by vacuum concentration was collected by filtration. trans-4-{[5-(6-bromopyridin-2-yl)thiazol-2-ylamino]methyl}cyclohexanecarboxylic acid methyl ester (2.02 g, 73%) was obtained by sequentially washing with water (10 ml), diethyl ether (10 ml) and drying in vacuo. 1H-NMR (400 MHz, DMSO-d6) delta: 8.15(1H,t,J=5.7 Hz), 7.83(1H,s), 7.74(1H,d,J=7.9 Hz), 7.63(1H,t,J=7.9 Hz), 7.31(1H,d,J=7.9 Hz), 3.15-3.06(2H,m), 2.32-2.19(1H,m), 1.97-1.87(2H,m), 1.85-1.76(2H,m), 1.63-1.49(1H,m), 1.37-1.23(2H,m), 1.06-0.93(2H,m).
The chemical industry reduces the impact on the environment during synthesis 727356-19-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; JAPAN TOBACCO INC.; US2006/205731; (2006); A1;,
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