Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 118289-16-0, name is 2-Bromopyridine-4-methanol. A new synthetic method of this compound is introduced below., Safety of 2-Bromopyridine-4-methanol
To the solution of i (18 g, 95.74 mmol) in toluene (180 mL) was added dropwise phosphorous tribromide (13.4 mL, 143.62 mmol) at 0 C. under inert atmosphere. The mixture was heated at 100 C. for 30 min. The reaction was cooled at 0 C. and NaHCO3 solution added followed by extraction with EtOAc (2*500 mL). The combined organic layer were dried (Na2SO4) and evaporated in vacuo. The residue was purified over silica eluting with 15% EtOAc:Hexane to obtain ii (12.0 g, 50%). 1H NMR (CDCl3, 400 MHz): delta 8.35 (d, J=4.8 Hz, 1H), 7.51 (s, 1H), 7.26 (d, J=6.0 Hz, 1H) and 4.34 (s, 2H). MS 251.80 [M+H]+.
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Reference:
Patent; Biota Europe Ltd.; Lunniss, Christopher James; Palmer, James T.; Pitt, Gary Robert William; Davies, David; Axford, Lorraine Claire; US2013/252938; (2013); A1;,
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