Application of 75711-00-1, Adding some certain compound to certain chemical reactions, such as: 75711-00-1, name is 2-Chloro-3-methoxy-5-nitropyridine,molecular formula is C6H5ClN2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75711-00-1.
A mixture of 4-chloro-lH-imidazole (2.72 g, 26.5 mmol), 2- chloro-3-methoxy-5-mtropyridme (5.0 g, 26.5 mmol), and KOH flakes 1.488 g, 26.5 mmol) in anhydrous DMSO (25 mL) was heated at 800C for 5 h. The reaction mixture was allowed to cool to rt and was poured into 1.0 L of water with vigorous stirring. The mixture was stirred at rt for 16 h. The precipitate was collected by vacuum filtration using a coarse sintered glass funnel. The solid was dried under high vacuum for 24 h to provide 2-(4-chloro- 1 H-imidazol- l-yl)-3-methoxy- 5- nitropyridine (5.22 g, 20.50 mmol, 77 % yield) as a light brown solid. LC-MS (M+H)+ = 255.0. 1H NMR (500 MHz, DMSO-^6) delta ppm 8.94 (d, J=2.44 Hz, 1 H) 8.51 (d, J=I.83 Hz, 1 H) 8.42 (d, J=2.44 Hz, 1 H) 8.02 (d, J=I.83 Hz, 1 H) 4.12 (s, 3 H).
According to the analysis of related databases, 75711-00-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MARCIN, Lawrence, R.; THOMPSON, Lorin, A., III; BOY, Kenneth, M.; GUERNON, Jason, M.; HIGGINS, Mendi, A.; SHI, Jianliang; WU, Yong-Jin; ZHANG, Yunhui; MACOR, John, E.; WO2010/83141; (2010); A1;,
Pyridine – Wikipedia,
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