Reference of 52605-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.
To Intermediate XIII (250 mg ; 0. 60 mmol) and 2-chloro-3-methoxypyridine (95 mg ; 0. 66 mmol) and 1, 1 -BIS (diphenylphosphino) ferrocene palladium (II) chloride (22 mg ; 0. 030 mmol) in 1,4-dioxane (4 mL) was added sodium carbonate solution (1 mL). The reaction mixture was heated at 150 for 15 min in a Smith microwave reactor. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate extracts were combined, washed with brine, dried over magnesium sulphate, filtered and evaporated under reduced pressure. The residue was purified by flash chromatography using ethyl acetate as eluant. The appropriate fractions were combined and evaporated under reduced pressure to give A solid. The solid was recrystallized from acetonitrile, collected by filtration and dried to give the title compound. Yield = 55 mg (23%)
The chemical industry reduces the impact on the environment during synthesis 52605-96-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/99177; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem