Application of 2604-39-9 , The common heterocyclic compound, 2604-39-9, name is 2-Chloro-5-nitropyridin-4-amine, molecular formula is C5H4ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
NBS (564 mg, 3.17 mmol) was added to a solution of 1 (500 mg, 2.88 mmol) in 8 mL of AcOH. The resulting mixture was stirred at 60 C for 4 h. After cooled to room temperature, the mixture was diluted with water. The precipitate was collected by filtration to afford 580 mg of 2 as a yellow solid, which was used in the next step without further purification. [M+Hj : 251.91, 253.96.
The synthetic route of 2604-39-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; ZHANG, Dengyou; ZHENG, Canhui; CHEN, Zhuo; LIU, Liu; HUANG, Liyue; YANG, Chao-Yie; (110 pag.)WO2018/213211; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem