Related Products of 72587-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 72587-18-9, name is 2-Chloro-5-(trifluoromethyl)pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.
N-[2-Chloro-5-(trifluoromethyl)pyridin-3-yl]-3-(ethylsulphanyl)imidazo[1,2-a]pyridine-2-carboxamide (XXVI-1) 1.1 mg (9.37 mmol) of thionyl chloride were added dropwise to a solution of 298 mg (1.33 mmol) of 3-(ethylsulphanyl)imidazo[1,2-a]pyridine-2-carboxylic acid in 10 ml of acetonitrile, and the mixture was heated under reflux for 3 h. The solvent was removed under reduced pressure and the residue was twice co-evaporated with toluene. The residue was dissolved in 3 ml of N,N-dimethylformamide. Separately, 263 mg (1.33 mmol) of 2-chloro-5-(trifluoromethyl)pyridine-3-amine were added to a suspension at 0 C., of 107 mg (2.67 mmol) of sodium hydride in 7 ml of N,N-dimethylformamide, and the mixture was stirred for another 30 min. The acid chloride solution prepared beforehand was then slowly added dropwise at 0 C. The reaction mixture was stirred at room temperature for a further 2 h. The mixture was poured onto ice-water and extracted twice with ethyl acetate. The combined organic phases were dried over sodium sulphate and the solvent was then removed. The crude product was purified by HPLC using a water/acetonitrile gradient as mobile phase. (log P (neutral): 4.39; MH+: 401; 1H-NMR (400 MHz, D6-DMSO) delta ppm: 1.09 (t, 3H), 2.98 (q, 2H), 7.22-7.25 (m, 1H), 7.55-7.60 (m, 1H), 7.82 (d, 1H), 8.66 (d, 1H), 8.73 (d, 1H), 9.07 (d, 1H).
According to the analysis of related databases, 72587-18-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; FISCHER, Ruediger; WILCKE, David; HAGER, Dominik; ILG, Kerstin; EILMUS, Sascha; GOeRGENS, Ulrich; TURBERG, Andreas; (71 pag.)US2018/116222; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem