Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Fluoro-3-(hydroxymethyl)pyridine
Step (ii)A solution of (2-fluoropyridin-3-yl)methanol (400mg, 3.1mmol), methanesulfonyl chloride (0.37mL, 4.7mmol) and triethylamine (0.88mL, 6.30mmol) in dichloromethane (lOmL) was stirred at rt for 16h. The mixture was then diluted with dichloromethane and washed with H20, then brine. The organic phase was collected, dried (MgS04) and concentrated in vacuo to give (2-fluoropyridin-3-yl)methyl methanesulfonate.
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Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
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