Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 1136-52-3
General procedure: A mixture of alpha4,3-O-isopropylidene pyridoxine, the respective saccharide and molecular sieves (4 A) was stirred under argon atmosphere in dry dichloromethane (5 mL) at rt for 1 h before it was cooled to 0 C. Silver triflate and N-iodosuccinimide (3.0 eq.) were added and the reaction mixture allowed to reach rt overnight. The mixture was diluted with dichloromethane (10 mL) and filtered through a pad of celite. Afterwards, the filtrate was washed with Na2S2O3 (10 % in water, 30 mL) and the aqueous phase was extracted with dichloromethane (3 x 40 mL). The combined organic layers were washed with distilled water (1 x 50 mL), brine (1 x 50 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product subjected to column chromatography using SiO2 (pentane/ethyl acetate 1/1 to 1/4, gradient elution) followed by C18 (methanol, isocratic) to afford the glycoside, which was used directly in the deprotection reaction.
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Reference:
Article; Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael; Carbohydrate Research; vol. 489; (2020);,
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