Electric Literature of 228410-90-0 ,Some common heterocyclic compound, 228410-90-0, molecular formula is C6H5BrN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 5-bromo-4-methyl-3-nitropyridin-2-ol (24 g, 103 rnmol) in DMF (200 ml) was added K2CO3 (21.39 g, 155 mmol) and CH3I (21.86 g, 155 mmol). The reaction mixture was stirred at room temperature for 2h. The reaction mixture was poured into ice cold water, the solid formed was filtered and dried under vacuum to afford title compound as off white solid (23.5 g, 92 %). FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, DMSO-d6) delta 8.40 (s, 1H), 3.51 (s, 3H), 2.21 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,228410-90-0, its application will become more common.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; BORUAH, Anima; CHITTY VENKATA, Srikanth; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/125408; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem