Adding a certain compound to certain chemical reactions, such as: 60186-13-2, 2,4,6-Trichloro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 60186-13-2, blongs to pyridine-derivatives compound. Product Details of 60186-13-2
(7) (R)-1-(2,6-dichloro-3-nitropyridin-4-yl)piperidine-3-tert-butyl carbamate To 30 mL solution of 2,4,6-trichloro-3-nitropyridine (1.14 g, 5.0 mmol) in ethanol was added triethylamine (1.4 mL, 10 mmol) at -10C, and stirred in an ice bath. After 15 mL solution of (R)-tert-butylpiperidin-3-yl-carbamate (1 g, 5.0 mmol) in ethanol was slowly added dropwise with a constant pressure funnel, the reaction solution was stirred for 1 h at -10C, and concentrated. The resultant crude product was subjected to silica gel column chromatography (ethyl acetate : petroleum ether = 1:2) to afford 0.78 g titled product with a yield of 39.9%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60186-13-2, 2,4,6-Trichloro-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Xuanzhu Pharmaco., Ltd.; EP2524917; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem