Synthetic Route of 60186-13-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60186-13-2, name is 2,4,6-Trichloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 1 (1.00 mmol) in DMF (3 mL) was added (PPh3)2PdCl2 (21 mg, 0.030 mmol) under an N2 atm and the reaction mixture was stirred for 5 min, before 2-furyl(tributyl)tin (0.32 mL, 1.0 mmol) was added. The resulting mixture was stirred for the time and at the temperature given in Table 1. H2O (40 mL) was added and the aqueous mixture extracted with EtOAc (2 × 30 mL). The combined organic phases were washed with brine (30 mL), dried (MgSO4) and evaporated in vacuo. The 1H NMR spectrum of the crude reaction mixture was recorded. The residue was dissolved in THF (8 mL), KF (ca. 200 mg) was added and the resulting suspension was stirred at ambient temperature for 18-20 h, evaporated with a small amount of silica gel and purified by flash chromatography on silica gel.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60186-13-2, 2,4,6-Trichloro-3-nitropyridine.
Reference:
Article; Khoje, Abhijit Datta; Gundersen, Lise-Lotte; Tetrahedron Letters; vol. 52; 4; (2011); p. 523 – 525;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem