Electric Literature of 60010-03-9, Adding some certain compound to certain chemical reactions, such as: 60010-03-9, name is 2,6-Dichloro-4-methyl-3-nitropyridine,molecular formula is C6H4Cl2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60010-03-9.
6-Chloro-4-methyl-3-nitro-2-pyrrolidin-1 -yl-pyridine (Intermediate compound)To a solution of crude 2,6-dichloro-4-methyl-3-nitro-pyridine (see previous reaction; 23.87g; 115mmol), pyrrolidine (11 ml 1.1 eq) in 100 ml_ acetonitrile was added TEA (ca. 50 ml 3eq). After stirring overnight at room temperature one aliquot of water was added to the reaction mixture and the acetonitrile was removed in vacuo. The remaining aqueous layer was extracted with EtOAc (3x15OmL). The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to yield a dark semi-solid. The crude material was purified by flash column chromatography (5-40% EtOAc in heptane) to yield 1 Og (26% over three steps) of the title compound as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60010-03-9, 2,6-Dichloro-4-methyl-3-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEUROSEARCH A/S; BROWN, William, Dalby; JESSEN, Carsten; MATTSSON, Cecilia; SOTT, Richard; STRØBAeK, Dorte; WO2010/122064; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem