Adding a certain compound to certain chemical reactions, such as: 25194-01-8, 2,6-Dichloro-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H2Cl2N2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C5H2Cl2N2O2
(1) Synthesis of an Intermediate, 2,6-dichloro-4-methoxypyridine To a tetrahydrofuran solution containing methanol (0.37 g, 0.0104*1.1 mol), sodium hydride (0.44 g (ca. 60% in mineral oil), 0.0104*1.05 mol) was added, then 2,6-dichloro-4-nitropyridine (2.00. g, 0.0104 mol) was added thereto and the resultant solution was stirred for about 2 hours at room temperature. After it was confirmed that there was no bubbling with the addition of methanol (1.0 g, 0.0355*0.9 mol), the resultant solution was stirred for about another 1 hour. After the reaction solution was partitioned between ethyl acetate and water, the obtained organic layer was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and thereafter concentrated to obtain the substantially pure end product. Yield: 1.63 g (88%). Solid. Melting point: 94 to 96 C. 1 H-NMR (60 MHz, CDCl3, delta): 3.79(3H, s), 6.70(2H, s).
The synthetic route of 25194-01-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US5691277; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem