Adding a certain compound to certain chemical reactions, such as: 15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine
A slurry of potassium carbonate (4.45 g, 32.2 mmol), potassium isopropenyltrifluoroborate (9b; 3.18 g, 21.46 mmol), PdCl2(AmPhos)2(0.152 g, 0.215 mmol), and 3-bromo-2-methoxy-5-nitropyridine (30b, 2.50 g, 10.73 mmol) in dioxane (50 mL) and water (20 mL) was sparged with nitrogen for 5 min, then placed in a sealed vessel and heated at 80 C for 1 h. The reaction mixture was then cooled to ambient temperature and partitioned between water and DCM. The organic layer was separated, and the aqueous layer was extracted with DCM (3×). The combined organic extracts were then dried over sodium sulfate, filtered, and concentrated in vacuo to give 2-methoxy-5-nitro-3-(prop-1-en-2-yl)pyridine (2.27 g, 11.69 mmol, >99% yield) as a red solid, which was used without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, and friends who are interested can also refer to it.
Reference:
Article; Lanman, Brian A.; Reed, Anthony B.; Cee, Victor J.; Hong, Fang-Tsao; Pettus, Liping H.; Wurz, Ryan P.; Andrews, Kristin L.; Jiang, Jian; McCarter, John D.; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Wang, Ling; Whittington, Douglas A.; Wu, Tian; Zalameda, Leeanne; Zhang, Nancy; Tasker, Andrew S.; Hughes, Paul E.; Norman, Mark H.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5630 – 5634;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem