Related Products of 1211540-92-9 , The common heterocyclic compound, 1211540-92-9, name is 3-Bromo-4-chloro-5-fluoropyridine, molecular formula is C5H2BrClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound (VII-17) (100 mg, 0.475 mmol),Compound (VIa-2) (146 mg, 0.523 mmol),(A-taPhos) 2 PdCl2 (16.8 mg, 0.0240 mmol)And cesium carbonate (310 mg, 0.950 mmol)Was dissolved in 1,4-dioxane (1.5 mL) and water (0.30 mL)Dissolved in the mixture, under microwave irradiation,And the mixture was stirred at 70 C. for 10 minutes.Water was added to the reaction solution,And extracted with chloroform.The solvent was distilled off under reduced pressure,The residue was purified by silica gel column chromatography (NH silica gel, n-hexane: ethyl acetate = 97: 3 ? 75: 25)Compound (I-97)(Yield 138 mg, Yield 79%)As a colorless oil.
The synthetic route of 1211540-92-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; Watanabe, Atsushi; Sato, Yuki; ogura, Keiji Tamada; Tatsumi, Yoshiyuki; (283 pag.)JP2018/145180; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem