Related Products of 6959-48-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6959-48-4, name is 3-(Chloromethyl)pyridine hydrochloride, molecular formula is C6H7Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of4(1.00 eq.) in DMF was added K2CO3(1.20-2.00 eq.). The reaction was stirred at room temperature for 1 h, followed by the addition of the alkyl halide (1.00-1.10 eq.). The reaction was stirred at room temperature for 0.5-24 h, concentrated under reduced pressure and purified by flash column chromatography (silica gel, solvent system I: petroleum ether ramping to 100% EtOAc, or solvent system II: DCM ramping to DCM/MeOH = 97:3) to give the desired product.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6959-48-4, 3-(Chloromethyl)pyridine hydrochloride.
Reference:
Article; Diab, Sarah; Abdelaziz, Ahmad M.; Li, Peng; Teo, Theodosia; Basnet, Sunita K.C.; Noll, Ben; Rahaman, Muhammed H.; Lu, Jingfeng; Hou, Jinqiang; Yu, Mingfeng; Le, Bich T.; Albrecht, Hugo; Milne, Robert W.; Wang, Shudong; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 762 – 772;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem