Application of 19355-04-5, Adding some certain compound to certain chemical reactions, such as: 19355-04-5, name is 3-Methoxy-4-nitropyridine 1-oxide,molecular formula is C6H6N2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19355-04-5.
EXAMPLE a) Preparation of 2-cyano-3-methoxy-4-nitropyridine A mixture of 12.5 g (12.5 moles) of the N-oxide of 3-methoxy-4-nitropyridine, 7.72 mL (1.1 eq.) of methyl sulphate and 70 mL of 1,2-dichloroethane is heated at 70 C. for 2.5 hours. It is allowed to cool and 70 mL of water are added. It is cooled in a salt and ice bath and, in portions, 7.55 g (2.1 moles) of sodium cyanide are added, controlling the temperature so as not to exceed 10 C. After 4 hours stirring, the reaction mixture is extracted with ethyl ether, the organic phase is washed with water, concentrated and the residue chromatographed (ethyl acetate/dichloromethane). There is obtained 7.06 g of a yellow oil (yield 53%).
According to the analysis of related databases, 19355-04-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nieto-Roman, Francisco; Vors, Jean-Pierre; Villier, Alain; Lachaise, Helene; Mousques, Adeline; Hartmann, Benoit; Hutin, Pierre; Molina, Jose Lorenzo; Muller, Benoit; US2003/191113; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem