Synthetic Route of 30766-11-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30766-11-1, name is 5-Bromopicolinic acid, molecular formula is C6H4BrNO2, molecular weight is 202.01, as common compound, the synthetic route is as follows.
General procedure: To the mixture of an appropriate amount of 4-bromo-pyridine-carboxylic acid 1 (0.90mmol) or 5-bromo-pyridine-carboxylic acid 2 (0.90mmol), substituted phenylboronic acid 3a-k (0.18mmol), anhydrous sodium carbonate (0.29g, 2.70mmol), 1,4-dioxane (30mL), H2O(10mL), and bis(triphenylphosphine)palladium(II) dichloride (0.09g, 0.135mmol) were added under an atmosphere of nitrogen at room temperature. The reaction mixture then was stirred at 100C for 5-8h and monitored by thin-layer chromatography (TLC). The reaction mixture was cooled to room temperature and the resulting precipitate was isolated by filtration to furnish the acid intermediate as the sodium salt, and then the solution was acidified to pH 5 to furnish the desired target compounds 4a-k and 5a-k.
Statistics shows that 30766-11-1 is playing an increasingly important role. we look forward to future research findings about 5-Bromopicolinic acid.
Reference:
Article; Zhu, Wufu; Wang, Wenhui; Xu, Shan; Tang, Qidong; Luo, Rong; Wang, Min; Gong, Ping; Zheng, Pengwu; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 812 – 819;,
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