Reference of 13534-98-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13534-98-0, name is 4-Amino-3-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of 3-Prop-1-ynyl-pyridin-4-ylamine (LXXIII). To a solution of LXXII (1.5 g, 8.67 mmol) in N,N-dimethyl formamide (20 mL) was added solid sodium acetate (2.1 g, 0.02106 mol). The resulting mixture was degassed for 10 min and then [1,1?- bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.31 g, 0.430 mmol), followed by tributyl(prop-1-yn-1-yl)stannane (3.7g, 11.3 mmol), were added. The reaction mixture 25 was heated at 100 C in a sealed tube for 12 h, before being allowed to cool to room temperature. The reaction mixture was poured in to water and the mixture was extracted 157 of 363 {//– DRAFT –//4069/3020WO/00228726/v2} 4069.3020 WO with ethyl acetate (3 x 50 mL). The combined organic extracts were dried over sodium sulfate and concentrated in vacuo. The crude product mixture was purified by column chromatography on (100-200 mesh) silica, using 3% methanol in dichloromethane as the eluant to afford LXXIII (1 g, 87%) as a semi solid.1H NMR (400 MHz, CDCl3) delta 8.29 5 (s, 1H), 8.08 (d, 2H, J= 5.7 Hz), 6.50 (d, 2H, J= 5.6 Hz), 4.61 (brs, 2H), 2.11 (s, 3H); MS (ESI, positive mode) m/z 133 (MH+).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13534-98-0, 4-Amino-3-bromopyridine.
Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; CULLEN, Matthew; HAUCK, Sheila; GENG, Bolin; FOLEY, Megan; BASTOS, Cecilia, M.; MUNOZ, Benito; HAEBERLEIN, Markus; WO2015/73528; (2015); A1;,
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