Adding a certain compound to certain chemical reactions, such as: 73583-37-6, 4-Bromo-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Bromo-2-chloropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 4-Bromo-2-chloropyridine
General procedure: Under Ar atmosphere, DMSO (2 mL), ArBr 1 (1.0 mmol), diethyl malonate 2 (1.5 mmol), CuI (0.1mmol), benzoxazole (0.2 mmol) and K3PO4 (3 mmol) were successively added into a sealed tube.The mixture was stirred at 50C for about 3-9 h. When the reaction completed indicated by TLC,the reaction mixture was poured into saturated ammonium chloride aqueous solution (20 mL)and extracted with ethyl acetate (3¡Á20 mL).The combined organic phase was washed with saturated ammonium chloride aqueous solution(2¡Á20 mL) and water (2¡Á20 mL). Then the separated organic layer was dried over anhydroussodium sulfate, filtered and concentrated under reduced pressure. The residue waschromatographed on silica gel using hexane/ethyl acetate to afford the desired product.
The synthetic route of 73583-37-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zeng, Yu; Zheng, Hao-Liang; Yang, Zhao; Liu, Cheng-Kou; Fang, Zheng; Guo, Kai; Synlett; vol. 29; 1; (2018); p. 79 – 84;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem