Adding a certain compound to certain chemical reactions, such as: 128071-98-7, 4-Bromo-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3BrFN, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3BrFN
4-bromo-2-fluoropyridine (1.55 g, 8.81 mmol), tert-butyl piperazine-1-carboxylate (2.46 g, 13.22 mmol) and potassium carbonate (3.65 g, 26.41 mmol) in dimethylsulphoxide (10 mL) was heated in a sealed tube at 100 ºC with stirring. After stirring overnight the mixture was cooled and ethyl acetate and water were added. The organic layer was washed with brine, dried (MgSO4) and evaporated. Purification of the residue by flash chromatography (100% hexanes to 1:4 hexanes /ethyl acetate) gave the title compound (2.33 g, 78%) as a white solid. LRMS (m/z): 342/344 (M+1)+. 1H NMR (300 MHz, , CDCl3) delta ppm 1.49 (s, 9 H), 2.49 (bs, 2 H), 3.63 (t, J=5.77 Hz, 2 H), 4.08 (d, J=2.75 Hz, 2 H), 6.05 (br s, 1 H), 7.21 (t, J=7.69 Hz, 1 H), 7.27 – 7.31 (m, 1 H), 7.36 – 7.40 (m, 1 H), 7.51 (t, J=1.79 Hz, 1 H)
The synthetic route of 128071-98-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Ines; EP2489663; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem