Application of 128071-98-7 ,Some common heterocyclic compound, 128071-98-7, molecular formula is C5H3BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of Compound 35.1 [0308] To a solution of 4-bromo-2-fluoropyridine (5.0 g, 28.6 mmol, 1.0 eq) in THF (50 mL) were added 2, 2′-oxydiethanol (9.1 g, 85.8 mmol, 3.0 eq) and t-BuOK (3.8 g, 34.3 mmol, 1.2 eq). After stirred at room temperature for 12 h, the reaction mixture was diluted with water (20 mL) and extracted with EA (20 mL x 3). The combined organic layers were washed with brine (20 mL x 5), dried over anhydrous Na2S04 , and concentrated under reduced pressure. The residue was purified by chromatography column (PE : EA = 3 : 1) to give 35.1 (6.4 g, yield: 86%) as a yellow oil; ESI-MS (M+H)+: 262.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,128071-98-7, its application will become more common.
Reference:
Patent; BIOGEN IDEC MA INC.; JENKINS, Tracy; VESSELS, Jeffery; WO2014/143672; (2014); A1;,
Pyridine – Wikipedia,
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