Reference of 81998-05-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 81998-05-2 as follows.
Under anitrogen atmosphere, triethylphosphite (2.0 mL, 120mmol) was added to a solution of 16 (343 mg, 1.30 mmol)in chloroform (10 mL) and the solution was refluxed for24 h. After cooling to room temperature, chloroform andexcess triethylphosphite were removed under reduced pressure. The residue waspurified by silica gel column chromatography with chloroform / ethyl acetate (v/v, 20/1)to give 17 (173 mg, 0.539 mmol, 41.5 %) as light yellow oil.1H NMR (CDCl3): = 8.61 (d, J = 5.1 Hz, 1H), 8.57 (d, J = 4.8 Hz, 1H), 8.32 (s, 1H),8.23 (s, 1H), 7.34-7.30 (m, 1H), 7.14 (d, J = 4.8 Hz, 1H), 4.07 (dq, J = 7.2 Hz, 4H), 3.24(d, J = 22 Hz, 2H), 2.44 (s, 3H), 1.27 (t, J = 7.2 Hz, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81998-05-2, its application will become more common.
Reference:
Article; Kodama, Koichi; Kobayashi, Akinori; Hirose, Takuji; Tetrahedron Letters; vol. 54; 40; (2013); p. 5514 – 5517;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem