With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10177-29-4, name is 4-Chloronicotinic acid, molecular formula is C6H4ClNO2, molecular weight is 157.5545, as common compound, the synthetic route is as follows.Recommanded Product: 4-Chloronicotinic acid
A mixture of amine 4 (1eq.), carboxylic acid (1.2 eq.), diisopropylethylamine (DIEA) (1.5 eq.), and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimidehydrogen chloride (EDC·HCl) (1.2 eq.) in dichloromethane was stirred at room temperature for18 h. The reaction mixture was diluted with dichloromethane and washed withwater and brine. The organic layer was dried over MgSO4 andconcentrated. The crude product was purified by normal phase column chromatography(SP1, Biotage) to yield compound 5.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10177-29-4, 4-Chloronicotinic acid, and friends who are interested can also refer to it.
Reference:
Article; Hwang, Jong Yeon; Smithson, David C.; Holbrook, Gloria; Zhu, Fangyi; Connelly, Michele C.; Kaiser, Marcel; Brun, Reto; Kiplin Guy; Bioorganic and Medicinal Chemistry Letters; vol. 23; 14; (2013); p. 4127 – 4131;,
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